2 edition of Polymeric scaffold synthesis and chemical modification for enhanced cell-polymer interaction. found in the catalog.
Polymeric scaffold synthesis and chemical modification for enhanced cell-polymer interaction.
Ting-Ting Tina Yu
Written in English
A polymeric scaffold was synthesized and chemically modified with bioactive peptides to promote neuron cell adhesion and guide neurite outgrowth for neural tissue engineering applications. Specifically, 2-hydroxyethyl methacrylate (HEMA) and 2-aminoethyl methacrylate (AEMA) monomers were co-polymerized to form a transparent hydrogel within which well defined channels were introduced using a fiber templating technique. P(HEMA-co-AEMA) scaffolds were fabricated and characterized. While these scaffolds themselves are non-adhesive to cells, they were chemically modified with a mixture of two laminin-derived peptides, CDPGYIGSR and CQAASIKVAV, through a crosslinking agent, sulfo-(N-maleimidomethyl)cyclohexane-1-carboxylate (sulfo-SMCC), to promote cell adhesion and neurite outgrowth. The peptide modified P(HEMA- co-AEMA) scaffolds were easily fabricated in aqueous conditions, highly reproducible, well-defined, and enhanced neural cell adhesion and guided neurite outgrowth of primary chick dorsal root ganglia neurons relative to non-peptide-modified controls.
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Univ. of Bristol Academic Rheumatology, UK. Offers a diverse collection of readily reproducible techniques for generating living cell-polymer constructs, through cell seeding to evaluation of final product. Also presents tips for troubleshooting. DNLM: Tissue Engineering - methods - . However, some recent articles featuring the use of polymeric scaffold structures in osteochondral engineering deserve citation here. Hydrogels incorporating agarose, alginate, Bone and Cartilage from Stem Cells: Growth Optimalization and Stabilization of Cell Phenotypes.
Full text of "Microgravity science & applications. Program tasks and bibliography for FY " See other formats. The term contemplates any manner by which a payload, agent or other material is incorporated into a subject polymer, including for example: attached to a monomer (by covalent or other binding interaction) and having such monomer be part of the polymerization to give a polymeric formulation, distributed throughout the polymeric formulation.
Water-soluble cellulose oligomer production by chemical and enzymatic synthesis: a mini-review auteur Elise Billes, Véronique Coma, Frédéric Peruch, Stéphane Grelier article Polymer International, Wiley, , 66 (9), pp - /pi Accès au bibtex titre. After 12 weeks, the composite scaffold had enhanced osteochondral regeneration towards hyaline cartilage and/or fibrocartilage compared with untreated defects that were filled predominantly with fibrous tissue. The cell-free composite scaffold containing PVA nanofibers, liposomes and growth factors enhanced migration of the cells into the.
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Cell Interactions with Polymers Protein adsorption to polymers. A polymeric material that is placed in solution or implanted in the body becomes coated with proteins quickly, usually within minutes.
Many of the subsequent interactions of cells with the material depend on, or derive from, the composition of the protein layer that forms on the Cited by: Basic principles: physical and chemical properties of polymeric biomaterials Chemistry is a constant factor from which the performance of most (polymeric) biomaterials can be predicted, but this.
The Polymeric scaffold synthesis and chemical modification for enhanced cell-polymer interaction. book material initially provides mechanical stability and also provides a template to guide three-dimensional cellular growth. The interaction of these two components, such as the coordination of polymer degradation rate with cellular synthesis rate, is critical for the success of tissue engineering.
Cells used in tissue engineeringCited by: 3. In book: Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (pp) Edition: 1st, Vol. 5; Chapter: Extracellular Matrix and Cell–Biomaterial Interactions: Tissue Genesis.
In tissue engineering, biomolecular recognition of synthesized organic support (scaffold) by cells is essential to enhance the volume and surface modification of biomaterials. This recognition can be accomplished through chemical or physical methods, using bioactive molecules such as chains of native ECM proteins and small peptide sequences Cited by: Therefore, this approach is currently being used for the synthesis of highly multifunctional polymeric scaffolds with controllable assembly and characteristics.
Peptide-based materials are now attractive candidates for biomedical used due to the progresses observed in synthesis methods and characterization techniques [1,4,5,6].Cited by: 6. chemical biology with an emphasis on carbohydrates and proteins.
These interests encompass synthetic protein and biocomponent design and use, as well as synthesis and methodology, protein engi-neering, molecular biology, and glycoscience with the goal of medicinal.
Hydrogels have existed for more than half a century, and today they have many applications in various processes ranging from industrial to biological. There are numerous original papers, reviews, and monographs focused on the synthesis, properties, and applications of hydrogels.
This chapter covers the fundamental aspects and several applications of hydrogels based on the old and the most Cited by: Polymer and Biomaterials Chemistry Group Experts in Synthesis, Characterisation and Simulation The Polymer and Biomaterials Research Group is a dedicated collaboration between several interdisciplinary research teams to study applied functions and uses in Polymer materials.
Thermoresponsive polymers are a class of “smart” materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest.
This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical Cited by: Design and synthesis of porous polymeric materials and their applications in gas capture and storage: a review.
Journal of Polymer Research25 (3) DOI: / by: Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the interstitial sites of their structures.
These polymers feature many amazing properties such as responsiveness to pH, time, temperature, chemical species and biological conditions besides a very Cited by: 1. Introduction. Conducting polymers (CPs) are a special class of polymeric materials with electronic and ionic conductivity.
They can be used in the dry or wet state (Xu et al. ) owing to their electronic conductivity, their porous structure or because of their processibility in microstructuring processes (Schultze & Karabulut ).The structures of the widely used CPs are depicted in Cited by: 5.
Synthesis and in vitro/in vivo response to peptide-polymer conjugates / Amy S. Chung and Weiyuan John Kao; ch. Synthesis of multi-epitopic glycopeptide-based cancer vaccines / Olivier Renaudet, Isabelle Bossu and Pascal Dumy; ch.
Stimuli-sensitive particles for drug delivery / Stephanie J. Grainger and Mohamed E. El-Sayed; ch. Transforming growth factor beta (TGFβ1) influences a host of cellular fates, including proliferation, migration, and differentiation.
Due to its short half-life and cross reactivity with a variety of cells, clinical application of TGFβ1 may benefit from a localized delivery strategy.
Photoencapsulation of proteins in polymeric matrices offers such an opportunity; however, the reactions Cited by: Book Written by Professor P. Kundu. Kundu, Patit Paban and Datta, Kingshuk (editors): A book entitled “Progress and Recent Trends in Microbial Fuel Cells” 1 st edition, 9 th June, ; published by Elsevier Science (UK), eBook ISBN: ; Paperback ISBN: Book Chapters written by Professor P.
Kundu. Robert S. Langer is one of 12 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member. Langer has written more than 1, articles. He also has over 1, issued and pending patents worldwide.
Langer’s patents have been licensed or sublicensed to over pharmaceutical, chemical, biotechnology and medical device companies.
Responses to strain include synthesis of growth factors, cytokines and hormones,93, changes in matrix synthesis,41,42,45,95 and cell alignment,45,90 Tensile forces have been shown to stimulate differentiation of mesenchymal cells towards a fibroblastic phenotype Hence, mechanical stimuli affect the preferential differentiation.
In addition, chemical hydrolysis as opposed to enzymatic reactions is responsible for degradation of polymeric chains in vivo; thus degradation does not vary from patient to patient. However, PCL is not without drawbacks, as with all synthetic polymers, PCL implants experience fibrosis and gradually become isolated from the surrounding bone.
from Passage 2 (P2) were used in the subsequent scaffold-cell interaction studies. Note that there is extensive data suggesting that these adherent cells exhibit multiple lineages when culture in vitro . hASC-scaffold Loading and Culture Based largely on the mechanical integrity and the regularity of micro-porous structures from SEMAuthor: Harish Chinnasami Shanmugam.
Corresponding author([email protected]) Open cell polymer derived ceramic (PDC) foams with high amount of porosity were fabricated from preceramic polymers by varying the parameters such as the type and the ratio of the polymeric precursor and blowing agent, pyrolysis temperature and atmosphere, and catalyst type.
In the method different types.chemical engineering graduates with a modem, industrially relevant education, including an emphasis on design and controls. Soon after, our Industrial Advisory Board agreed that the time was ripe for the chemical engineering program to develop a biochemical engineering emphasis.
In this regard, the chemical engineering and biology team found.1. Materials Challenges in Regenerative Medicine 15 and availability of a medical product and service and therapy, a reduced risk of treatment failure, in particular with customised medical products according to a patient’s individual anatomical features, and last but not least, a reduced therapy discomfort for the patient and his/her family.